Sustainable synthesis of ciclopentene derivatives through multicomponent reactions in continuous flow regime

Sustainable synthesis of ciclopentene derivatives through multicomponent reactions in continuous flow regime

Autor: Marca: Dial騁ica Refer麩cia: 9786527006978

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At present, a highly efficient tool for organic synthesis is the combination of organocatalytic and multicomponent processes. In the organocatalysis reaction it is possible to generate a reactive intermediate with high enantioselectivity and later, in the multicomponent stage, the complexity and structural diversity of the process increases. This strategy allows the synthesis of various analogues of optically active natural compounds and biologically relevant molecules of pharmacological interest, which are essential for human life.

The current study, which is divided into three chapters, describes a methodology for the synthesis of tetrasubstituted cliclopentene derivatives from an organocatalytic reaction, followed by a multicomponent Ugi-type reaction under continuous flow regime. The use of green solvents in each reaction step, as well as the adoption of flow chemistry, led to obtaining products with high yield and enantiomerically-enriched in a fast and efficient manner, allowing the development of more sustainable strategies in synthetic chemistry.



Caractersticas

  • Ano: 2024
  • Autor: Yoisel Bueno Broterson
  • Selo: Dial騁ica
  • ISBN: 9786527006978
  • Nコ de P疊inas: 152
  • Capa: Flexvel


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At present, a highly efficient tool for organic synthesis is the combination of organocatalytic and multicomponent processes. In the organocatalysis reaction it is possible to generate a reactive intermediate with high enantioselectivity and later, in the multicomponent stage, the complexity and structural diversity of the process increases. This strategy allows the synthesis of various analogues of optically active natural compounds and biologically relevant molecules of pharmacological interest, which are essential for human life.

The current study, which is divided into three chapters, describes a methodology for the synthesis of tetrasubstituted cliclopentene derivatives from an organocatalytic reaction, followed by a multicomponent Ugi-type reaction under continuous flow regime. The use of green solvents in each reaction step, as well as the adoption of flow chemistry, led to obtaining products with high yield and enantiomerically-enriched in a fast and efficient manner, allowing the development of more sustainable strategies in synthetic chemistry.

Deixe seu comentário e sua avalia鈬o







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  • Avalia鈬o:
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  • Ano: 2024
  • Autor: Yoisel Bueno Broterson
  • Selo: Dial騁ica
  • ISBN: 9786527006978
  • Nコ de P疊inas: 152
  • Capa: Flexvel


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